{"product_id":"kpv-5-mg","title":"KPV – 5 mg","description":"\u003cdiv class=\"qvg-desc-rt\"\u003e\n\u003cstyle\u003e.qvg-desc-rt{font-family:'Neue Montreal',Helvetica,Arial,sans-serif;color:#6f7f84}.qvg-desc-rt p{margin:0 0 15px;font-size:15.5px;font-weight:300;line-height:1.7}.qvg-desc-rt strong{color:#233137;font-weight:500}.qvg-desc-rt em{color:#8a969b}.qvg-desc-rt sup{line-height:0}.qvg-desc-rt sup a{font-size:11px;font-weight:600;color:#758084;text-decoration:none;padding:0 1px}.qvg-desc-rt sup a:hover{color:#233137}\u003c\/style\u003e\n\u003cp\u003e\u003cstrong\u003eKPV\u003c\/strong\u003e is the tripeptide \u003cstrong\u003eLys-Pro-Val\u003c\/strong\u003e, the C-terminal residues 11-13 of \u003cstrong\u003eα-MSH\u003c\/strong\u003e and the smallest melanocortin fragment reported to retain anti-inflammatory activity.\u003c\/p\u003e\n\u003cp\u003eIn gut epithelial and immune cells, KPV enters via the di\/tripeptide transporter \u003cstrong\u003ePepT1\u003c\/strong\u003e; at \u003cstrong\u003enanomolar\u003c\/strong\u003e levels it inhibited \u003cstrong\u003eNF-κB\u003c\/strong\u003e and MAP kinase signaling and cut pro-inflammatory cytokine output\u003csup\u003e\u003ca href=\"https:\/\/doi.org\/10.1053\/j.gastro.2007.10.026\" target=\"_blank\" rel=\"noopener\"\u003e[1]\u003c\/a\u003e\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003eIt acts \u003cstrong\u003einside the cell\u003c\/strong\u003e, not on surface receptors: in a peritonitis model its anti-migratory effect was \u003cstrong\u003enot blocked by an MC3\/MC4 antagonist\u003c\/strong\u003e; unlike core α-MSH peptides it did \u003cstrong\u003enot raise cAMP\u003c\/strong\u003e\u003csup\u003e\u003ca href=\"https:\/\/doi.org\/10.1124\/jpet.103.051623\" target=\"_blank\" rel=\"noopener\"\u003e[2]\u003c\/a\u003e\u003c\/sup\u003e. The record is preclinical.\u003c\/p\u003e\n\u003cp\u003eSupplied as a \u003cstrong\u003elyophilized powder\u003c\/strong\u003e for reconstitution. \u003cem\u003eFindings above come from preclinical (animal and cell-based) research on these molecules and are provided as scientific reference for laboratory research only.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Qovigen Peptides","offers":[{"title":"Default Title","offer_id":49587397066979,"sku":"KPV5","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0777\/1029\/5267\/files\/qovigen-kpv-5mg.webp?v=1787559310","url":"https:\/\/qovigen.com\/products\/kpv-5-mg","provider":"Qovigen Peptides","version":"1.0","type":"link"}